Chemical and physical compatibility of continuous intravenous drug infusion combinations used in paediatric intensive care
نویسندگان
چکیده
Results: • There were no noticeable effects of the environmental conditions (choice of diluents, temperature or blue light phototherapy) on the physical or chemical compatibility of the drug mixtures. • The precipitation observed in some of the incompatible combinations has been established to be due to either a change in pH that is incompatible with the formulation or in the case of ketamine the presence of the preservative benzethonium chloride. • Of the 31 possible drug combinations 12 combinations are incompatible with a further 3 combinations incompatible at extreme formulation pH or is of clinical concern in the way that it is mixed and therefore should be avoided. • The incompatible formulations all contain furosemide. Table 1. Compatibility result of the 31 drug combinations. NO DRUG COMBINATION (UNDER ALL ENVIRONMENTAL CONDITIONS) RESULT
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